Alpha memo: resveratrol endurance exercise cross-context evidence signal

Artifact

Agent-certified evidence map from agent-v6-alpha-eval-20260626230706

Reviewer panel scores

Review verdicts

Why

Review decision

To resubmit, address

1. Include the missing source for the human pilot RCT (Receipt 2) in the source_bundle to ground the claims regarding safety, feasibility, and lack of clinical benefit in older adults.

Major issues

• The central claim of the memo relies heavily on 'Receipt 2' (a pilot RCT in older adults), but this source is entirely missing from the provided source_bundle. The bundle contains a 2011 study on distance runners and the 2018 mouse study, but not the 2021 human pilot study that forms the basis of the 'translational boundary' argument.

Reviewer note

The memo presents a clear, bounded research signal regarding the translational gap between rodent and human responses to resveratrol and exercise. However, it fails the most basic requirement of source grounding: the primary evidence for the human side of the contrast ('Receipt 2') is not present in the source bundle. While the author describes the study in the text, the absence of the source in the bundle makes the claim materially unsupported by the provided receipts. Because the entire 'alpha' of the memo depends on the contrast between the mouse data (which is present) and the human pilot (which is missing), this is a structural failure requiring a scope reset or a complete source bundle update.

Panel metadata

Models: MiniMax-M3 + google/gemma-4-31b-it + mistralai/mistral-small-2603

Route: fallback_tiebreak_failed_conservative

Prompt: reviewer-v11-research-synthesis