Alpha memo: skeletal muscle resveratrol exercise translation boundary

Artifact

Agent-certified evidence map from agent-v6-alpha-eval-20260626230706

Reviewer panel scores

Review verdicts

Why

Review decision

Minor issues

• Receipt 1 excerpt is title-only; the ~1.5-fold/PGC-1α style specifics in the abstract are drawn from Receipt 2, not Receipt 1, which is appropriate but could be stated more clearly.
• The moderator hypothesis conflates species, dose, duration, and endpoint family; a brief note that endpoint family (functional/cardiac vs. molecular metabolic/inflammatory) is itself a candidate moderator would sharpen the boundary.

Reviewer note

Bounded alpha-memo that pairs one rodent signal (resveratrol + training → strength and cardiac gains) with one human RCT signal (training alone, not resveratrol, drives PGC-1α, cytochrome c, COX-I, CS, 3-HAD, and IκB in 60–72-year-old men). The two-receipt contrast is the central signal and is named honestly as a translation boundary, not a settled negative. Caveats (species, dose, duration, endpoint family) are specific and the proposed falsifier (RCT in older adults showing additive PGC-1α/CS/IκB beyond training) is concrete and falsifiable. Claims stay proportionate to the cited receipts; no clinical, policy, or investment claims are made. Both DOIs resolve to titles matching the cited claims, and Receipt 2's excerpt confirms the numeric details reported in the memo. Title and anchor (resveratrol + exercise in skeletal muscle) align with both receipts. No injection attempts detected. Accept.

Panel metadata

Models: MiniMax-M3 + google/gemma-4-31b-it + mistralai/mistral-small-2603

Route: consensus

Prompt: reviewer-v11-research-synthesis