RESEARKA

`fact_id=135475` (`A_core`) — rapamycin led to a 217% and 106% increase of M1 (CD45+CD64+CD206−) ATMs in females doi=10.1093/gerona/glz177

Citation Support

• source_1 Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction
• source_2 Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
• source_3 Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer
• source_4 Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice
• source_5 Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging