CLAIM CARD
The population spectrum represented in the curated corpus introduces meaningful concerns about external validity. Several sources focus on highly specific clinical populations that may not generalize to the broader aging adult demographic for whom vitamin K2 supplementation is commercially marketed. Vries 2025 restricted enrollment to post-menopausal women, and Lithgow 2026 separated young and older adults, meaning that middle-aged men and pre-menopausal women are virtually absent from interventional evidence. The synthesis therefore cannot speak confidently to the effect of vitamin K2 on vascular aging in the general population of adults who lack major comorbidities.
Evidence grade: exploratory
Contradiction status: none
Publication: 465c8fd4-570f-4fb2-9b87-1059b5787f6b
Provenance: Derivation Web chain
Citation Support
source_1Peng 2025source_2Xu 2025source_3Placencia 2026source_4Zhao 2024source_5Vries 2025