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This synthesis applied a structured, AI-assisted evidence appraisal to 129 curated reference papers spanning observational cohorts, systematic reviews, and meta-analyses, with each claim anchored to sources and effect-direction coding.

Evidence grade: exploratory

Contradiction status: non_supportive

Publication: 4e939420-aa6e-4b0e-9f24-335cb59cf96d

Provenance: Derivation Web chain

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