CLAIM CARD
Several outcome domains in this synthesis rest on a single source document, precluding internal replication within the corpus. The skeletal-fracture domain rests on Morita 2025, a systematic review of preclinical bone-regeneration studies without any enrolled human sample. Findings that emerge from only one source cannot be cross-validated within the curated evidence base, and any single-study estimate—however statistically significant—remains vulnerable to unmeasured confounding, selection bias, or idiosyncratic methodological choices unique to that investigation.
Evidence grade: exploratory
Contradiction status: none
Publication: ec49b21a-665d-471c-b2c4-8ab5a5943e34
Provenance: Derivation Web chain
Citation Support
source_1Murray 2025source_2Mielke 2025source_3Zumerle 2024source_4Mury 2025source_5Zhao 2024