CLAIM CARD
Mechanistically, the AGE–RAGE axis provides a plausible biological substrate linking glycation to tissue damage across multiple organ systems. The systematic review by Xu 2023 examined AGE effects on primary stem cell differentiation potential, providing in-vitro mechanistic context for the clinical observations. Zhang 2025 synthesized intervention evidence, reporting that three months of Vaccinium myrtillus extract at 600 mg/day reduced carboxymethyllysine levels in healthy subjects, though carboxyethyllysine was not significantly changed, suggesting pathway-specific AGE modulation.
Evidence grade: exploratory
Contradiction status: none
Publication: 88f190ad-b3cd-4533-8b95-219d3a357339
Provenance: Derivation Web chain
Citation Support
source_1Movahedian 2025source_2Kopytek 2025source_3Chang 2025source_4Wu 2025source_5Li 2026