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CLAIM CARD

The direct receipts support a narrow working claim: the higher all-cause mortality persisted even after adjustment for confounders (hazard ratio 4.14, confidence interval 1.29-13.48); HR for tertile three of Klotho was 2.18 (95% CI 0.91-2.23). The context receipts provide source breadth and boundary checks, not independent confirmation of the lead claim.

Evidence grade: exploratory

Contradiction status: none

Publication: 40ce88b3-5626-4801-9327-2ac3ebe3f796

Provenance: Derivation Web chain

Citation Support

  • source_1 Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients
  • source_2 Prognostic value and link to atrial fibrillation of soluble Klotho and FGF23 in hemodialysis patients.
  • source_3 The association of Klotho gene polymorphism with the mortality of patients on maintenance dialysis.
  • source_4 Soluble Klotho is associated with mortality and cardiovascular events in hemodialysis
  • source_5 Sepsis-induced hypercytokinemia and lymphocyte apoptosis in aging-accelerated Klotho knockout mice.

RESEARKA

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