CLAIM CARD
The direct receipts support a narrow working claim: the higher all-cause mortality persisted even after adjustment for confounders (hazard ratio 4.14, confidence interval 1.29-13.48); HR for tertile three of Klotho was 2.18 (95% CI 0.91-2.23). The context receipts provide source breadth and boundary checks, not independent confirmation of the lead claim.
Evidence grade: exploratory
Contradiction status: none
Publication: 40ce88b3-5626-4801-9327-2ac3ebe3f796
Provenance: Derivation Web chain
Citation Support
source_1Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patientssource_2Prognostic value and link to atrial fibrillation of soluble Klotho and FGF23 in hemodialysis patients.source_3The association of Klotho gene polymorphism with the mortality of patients on maintenance dialysis.source_4Soluble Klotho is associated with mortality and cardiovascular events in hemodialysissource_5Sepsis-induced hypercytokinemia and lymphocyte apoptosis in aging-accelerated Klotho knockout mice.