RESEARKA

Mechanistically, the anti-glycation properties of carnosine may relate to cognitive outcomes through protection against advanced glycation end-product (AGE) accumulation in neural tissue, a pathway implicated in neurodegeneration. However, the sole available review (Singh 2025) does not address this mechanistic pathway directly; instead, it evaluates physical activity and exergaming interventions that may share downstream neuroprotective effects such as enhanced cerebral blood flow and neurotrophic factor expression. Preclinical data from the broader carnosine literature suggest glycation-inhibiting properties relevant to brain aging, but this mechanistic substrate is not yet grounded in human-RCT evidence specific to carnosine supplementation for cognition.

Citation Support

• source_1 Movahedian 2025
• source_2 Kopytek 2025
• source_3 Kabthymer 2024
• source_4 Li 2025
• source_5 Dahlen 2025