CLAIM CARD
The curated corpus is composed exclusively of observational cohort studies, systematic reviews, and preclinical animal models; no randomized controlled trials of retinal-age-gap-guided intervention appear in the reference set. This absence means that the causal arrow from an accelerated retinal age gap to downstream clinical action — screening escalation, treatment initiation, or preventive counseling — remains untested within this evidence base. The limitation is therefore not one of association strength but of intervention proof: the synthesis cannot address whether retinal-age-gap biomarkers meet the bar for clinical decision-making that would require prospective, randomized validation.
Evidence grade: exploratory
Contradiction status: none
Publication: df81d398-48f0-4b72-9ba2-3a198be21ae8
Provenance: Derivation Web chain
Citation Support
source_1Nonaka 2026source_2Zhu 2023source_3Chen 2023source_4Chen 2025source_5Miao 2025