RESEARKA

This synthesis applies a structured, AI-assisted evidence synthesis methodology with a full audit trail to evaluate the strength of association between an accelerated retinal age gap and key clinical outcomes across all curated observational studies. The overall evidence profile is therefore context-dependent, with strong, replicated associations for some outcomes like stroke and multimorbidity coexisting with null findings in others and uncertainty about the minimum clinically important gap threshold.

Citation Support

• source_1 Nonaka 2026
• source_2 Zhu 2023
• source_3 Chen 2023
• source_4 Chen 2025
• source_5 Miao 2025