CLAIM CARD
Meta-analytic and systematic review evidence offers further context for interpreting these clinical findings. Griffin 2017 synthesized RCT evidence on metformin and cardiovascular disease, noting participants were mainly white, aged ≤65 years, overweight/obese, and reporting effect sizes including a Mantel-Haenszel RR for all-cause mortality of 0.9.
Evidence grade: exploratory
Contradiction status: none
Publication: 5f566366-fb20-4402-ba24-c1117573f97f
Provenance: Derivation Web chain
Citation Support
source_1Zaveri 2026source_2Wu 2026source_3Hong 2026source_4Lee 2026source_5Seo 2026