CLAIM CARD
The corpus lacks long-term mortality and hard clinical endpoint data. No included study was designed with long-term survival as a primary endpoint in the aging-relevant population. The mechanism-to-clinic gap therefore remains wide: while preclinical data convincingly demonstrate anti-inflammatory and regenerative properties of EVs (Zhu 2025, Hong 2025), the translation to clinically meaningful, sustained benefit in older adults is not established by the available human evidence.
Evidence grade: exploratory
Contradiction status: none
Publication: 3fa5cd13-7439-4f62-b446-2c8e84c03e7e
Provenance: Derivation Web chain
Citation Support
source_1Jafarzadeh 2025source_2Leung 2025source_3Bolandnazar 2024source_4Wu 2025source_5Kishta 2025