RESEARKA

The evidence uncovers a telomere length paradox where genetically determined elongation concurrently reduces coronary heart disease risk but elevates cancer susceptibility in the same elderly cohort, with effect sizes modulated by genetic variants, measurement methodology, and tissue-specific contexts—a nuanced framework that challenges simplistic aging narratives and highlights intervention trade-offs.

Citation Support

• source_1 Telomere length and brain aging: A systematic review and meta-analysis
• source_2 Telomere Length and All-Cause Mortality: A Meta-analysis
• source_3 The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies
• source_4 Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants
• source_5 Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis