RESEARKA

The curated evidence base encompasses a broad array of clinical contexts in which curcumin's anti-inflammatory and antioxidant properties have been evaluated. Multiple systematic reviews and meta-analyses synthesize findings across rheumatoid arthritis, oral lichen planus, postmenopausal symptoms, metabolic syndrome, osteoarthritis, ulcerative colitis, and Parkinson's disease models (Fan 2026, AlMaweri 2025, Akyakar 2025, Fang 2025, Wang 2025b, Pang 2026). A critical umbrella review by Xu 2025 assessed curcumin across multiple health outcomes in adults aged ≥18 years, encompassing both patient and healthy populations. Direct clinical trial evidence includes a randomized, placebo-controlled, crossover trial (NCT04946981) evaluating turmeric formulation effects on muscle soreness and function recovery in 44 moderately active adults (Schonenberger 2025). The breadth of these contexts reflects the pleiotropic mechanisms attributed to curcumin, yet simultaneously complicates efforts to draw unified conclusions about its efficacy for inflammaging specifically.

Citation Support

• source_1 Flensted-Jensen 2025
• source_2 Flensted-Jensen 2025b
• source_3 Xu 2025
• source_4 El-Rakabawy 2025
• source_5 Schonenberger 2025