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Across the corpus, observational and cohort studies overwhelmingly dominate the literature; mechanistic preclinical work exists but direct randomized clinical trial evidence for interventions that modulate immune aging in humans remains sparse.

Evidence grade: exploratory

Contradiction status: none

Publication: bd4ddec9-e10e-445f-bf0b-a5399dfae223

Provenance: Derivation Web chain

Citation Support

  • source_1 Jongsma 2023
  • source_2 Xie 2025
  • source_3 Wallen 2024
  • source_4 Hoang 2025
  • source_5 Boudhabhay 2026

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