RESEARKA

What does the current evidence establish about Colchicine Inflammaging and human geroscience? This paper synthesizes colchicine inflammaging as an aging-related intervention across 37 included source papers and 1511 high-confidence extracted claims. The evidence profile contains 3 direct clinical sources, 18 adjacent clinical sources, and no sources classified primarily as mechanistic or model-system evidence, with 113 cross-study disagreements across the evidence base. Positive study-level signals concentrate in the dosing and pharmacokinetics, longevity and immune outcome classes, null signals in the contextual adjacent evidence, cardiometabolic and dosing and pharmacokinetics outcome classes, and negative signals in the contextual adjacent evidence and longevity outcome classes. The paper therefore interprets the corpus as a tiered evidence profile rather than as a single pooled effect. The conclusion is that colchicine inflammaging remains a bounded geroscience case: mechanistic plausibility and selected clinical signals justify further targeted testing, while mixed and null findings limit any unqualified anti-aging claim. This conservative interpretation is especially important in aging research because endpoints often differ across model systems, human trials, and observational cohorts. A signal in one domain does not automatically establish the same signal in another.

Citation Support

• source_1 Mohammadnia 2025
• source_2 Li 2025
• source_3 Ammirati 2026
• source_4 Pascart 2026
• source_5 Broekhoven 2022