RESEARKA

Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.

Citation Support

• source_1 Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction
• source_2 Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
• source_3 Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer
• source_4 Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice
• source_5 Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging