CLAIM CARD
A fundamental limitation of this synthesis is the composition of the curated evidence corpus. Although 56 papers were included, the majority are systematic reviews and meta-analyses of preclinical animal studies rather than primary human randomized controlled trials. For example, evidence for osteoporosis-related bone outcomes (Zhang 2025, He 2023, Zhang 2025b), periodontal regeneration (Zhou 2025), diabetic peripheral neuropathy (Lu 2025), and renal ischemia-reperfusion injury (Wang 2025) derives entirely from preclinical models.
Evidence grade: exploratory
Contradiction status: none
Publication: 3fa5cd13-7439-4f62-b446-2c8e84c03e7e
Provenance: Derivation Web chain
Citation Support
source_1Jafarzadeh 2025source_2Leung 2025source_3Bolandnazar 2024source_4Wu 2025source_5Kishta 2025