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The evidence base for rapamycin's contextual effects spans diverse study designs, populations, and endpoints across the 16 curated references. Gkioni 2025 demonstrated that rapamycin combined additively with trametinib to extend mouse healthspan and lifespan, with effects reaching significance on multiple endpoints.

Evidence grade: exploratory

Contradiction status: none

Publication: 1ece772b-d3e4-4ad0-b090-ac7e9ea4a1d6

Provenance: Derivation Web chain

Citation Support

  • source_1 Mandrioli 2023
  • source_2 Lin 2022
  • source_3 Moel 2025
  • source_4 Gkioni 2025
  • source_5 Zhou 2024

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