RESEARKA

`fact_id=166319` (`A_core`) — Metformin (0.1%) combined with rapamycin (14 ppm) robustly extended lifespan, suggestive of an added benefit. doi=10.1111/acel.12496

Citation Support

• source_1 Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction
• source_2 Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
• source_3 Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer
• source_4 Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice
• source_5 Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging