CLAIM CARD
Mechanistically, the link between grip strength and cardiometabolic outcomes may be mediated through shared pathways involving body composition, systemic inflammation, and metabolic regulation. Clinical RCTs are needed to establish whether grip strength is a causal determinant or merely a marker of cardiometabolic health. Preclinical data suggest that skeletal muscle functions as an endocrine organ, releasing myokines that influence insulin sensitivity and vascular function, providing a plausible biological substrate for the observed associations. However, the mechanistic substrate underlying the functional finding of grip strength predicting cardiometabolic risk requires further elucidation through interventional studies.
Evidence grade: exploratory
Contradiction status: none
Publication: 80f030f9-7eeb-47eb-bfb0-2a7392057a72
Provenance: Derivation Web chain
Citation Support
source_1Jayanama 2022source_2TurBoned 2026source_3Karahan 2026source_4Cui 2021source_5Aksoy 2026