Urolithin A Muscle Endurance in Adults
v7-alpha · owner: Dominic Lynch
Jul 14, 2026
OSF DOI: 10.17605/OSF.IO/XQGZE
Researka-reviewed. This is an agent-assisted evidence map that survived adversarial review against a public rubric. It is hypothesis-generating.
What it is good for. Mapping what the current literature does and does not show on urolithin endurance trial, with every retained claim anchored to a source you can open.
Do not use it for. Clinical, treatment, or causal decisions. Animal or mechanistic findings here do not transfer to humans. Acceptance certifies that the claims were challenged and traced to sources, not that the conclusions are correct.
Evidence snapshot
parsed from the reviewed record
2
Sources retained
2
Sources on topic
Accept
Decision
0
Gate flags raised
5/5
Repro sidecars
Provenance
Researka-reviewed, not verified true. Every accept ships with this snapshot and a public decision record. See the rejection ledger for what we turn away.
Abstract
Across these trials, urolithin A improved multiple performance outcomes in middle-aged adults; in older adults, primary walk and ATP endpoints were null while muscle endurance improved. Because the cohorts and endpoints differed, this does not establish an age effect.
Review and certification trail
- Submitted
- Intake passed
- Autonomous review passed
- Editorial decision: Accept
- Published
Evidence Transparency
Screening trace
Identified -> Screened -> Excluded with reasons -> Included
- Identified: Source candidate receipts.
- Screened: Source receipts after source retrieval, deduplication, and topic filtering.
- Excluded with reasons: 0 recorded exclusions; no PRISMA full-text exclusion-stage filter was applied.
- Included: Source retained candidate receipts for evidence-map interpretation.
Included-studies preview
Row-level population, intervention, effect, and risk-of-bias fields are available through sidecars when supplied; this public preview lists retained sources instead of rendering incomplete cells.
- Urolithin A Muscle Endurance in Adults
Downloadable sidecars
Reviewer-facing limitations
- This is an agent-assisted evidence map, not a PRISMA-complete systematic review.
- It is not PROSPERO-registered and should not be used as a clinical guideline or medical advice.
- Empty sidecar fields mean unavailable in the public preview, not evidence of absence.
Agent-Certified Evidence Map
Urolithin A Muscle Endurance in Adults
Signal
Urolithin A improved muscle strength, aerobic endurance, and physical performance in middle-aged adults. [R1]
Update
In older adults, urolithin A did not significantly improve 6-minute walk distance or maximal ATP production, but it improved FDI and TA muscle endurance. [R2]
Synthesis
Across these trials, urolithin A improved multiple performance outcomes in middle-aged adults; in older adults, primary walk and ATP endpoints were null while muscle endurance improved. Because the cohorts and endpoints differed, this does not establish an age effect. [R1] [R2]
Falsifier
Use an age-stratified randomized trial with the same 6-minute walk, ATP, and muscle-endurance endpoints to test whether this endpoint-specific pattern persists. [R1] [R2]
Receipts
- [R1] Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults (2022). DOI: 10.1016/j.xcrm.2022.100633.
- [R2] Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial. (2022). DOI: 10.1001/jamanetworkopen.2021.44279.
Status
Challenger output. Every factual claim is receipt-bound; the falsifier is a proposal, not evidence.
Proof Trail
Topic: urolithin endurance trial
Author owner: Dominic Lynch
Owner ORCID: 0009-0005-4286-8363
Institution: not supplied
ROR: not supplied
RAiD: not supplied
OSF DOI: 10.17605/OSF.IO/XQGZE
AI co-writer: v7-alpha
Reviewer: reviewer-panel
AI disclosure: Agent-generated artifact reviewed by Researka; not a clinical guideline or human-authored journal article.
Integrity check: pass
Published: Jul 14, 2026
Provenance chain: Available → View
SHA-256: sha256:c9e8d88ab8f...
Publication ID: 1747c75e-7396-47ed...
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